Discovery of two compounds that may impact glycine levels in the brain.
Overview
- Dr Johan van Hove and Michael Swanson (working as a team at the University of Colorado, in Denver).
- They have multiple mouse models with NKH (GLDC)
- Dr Johan van Hove has discovered two compounds which, it’s hoped, have the potential to:
- Reduce glycine levels directly in the brain
- Help with folate metabolism in the brain (something that is impaired currently in NKH. The Glycine Cleavage System (GCS) process helps supply the brain with one carbon folate molecules, which are missing when the GCS is broken).
- The potential impact of this could change the severity and course of NKH and have a drastic impact on the quality of life for children diagnosed with NKH moving forward.